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控制的siRNA释放纳米聚合物用于动物模型中有效的向抗癌疗法

Jingchao Jia^1,2, Jing Yang³, Leimin Qian²

¹Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

International journal of nanomedicine

|February 12, 2024

概括

这项研究开发了一种用于近红外 (NIR) 光控制的siRNA释放的新型纳米聚合物,增强了抗瘤治疗. 该系统精确地将siRNA传递给瘤,显著抑制瘤生长并提高治疗安全性.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

针对抗瘤治疗的小干扰RNA (siRNA) 的空间时间控制释放面临挑战,原因是对光响应触发器的限制.
接近红外线 (NIR) 光提供深层组织透和最小的侵入性,使其理想适用于体内应用,但传统的光敏感键在紫外线/可见光谱中吸收.

研究的目的:

开发一种由NIR控制的siRNA释放系统,用于增强抗瘤RNA干扰 (RNAi) 疗法.
为了创建一个nanopolyplex能够共同交付siRNA和上转化纳米粒子 (UCNPs) 针对癌症治疗.

主要方法:

合成了一种对紫外线敏感的triblock共聚合物,cRGD-多乙烯甘醇-多乙烯酸-5- 2'-dimethylamino-ethoxy-2-nitrobenzyl alcohol-多乙烯氨酸 (cRGD-PEG-PAspED-ONB-PPHE).
组装了共聚合物与疏水性上转化纳米粒子 (UCNPs) 形成一个阴离子微粒 (T-UCNP).
复杂的T-UCNP与siRNA (特别是siRNA-PLK1) 组合在一起,以创建用于抗瘤治疗的纳米多重复合T-si/UCNP.

主要成果:

T-PLK1/UCNP纳米复合体通过cRGD修改证明了有效的瘤细胞向.
通过使用UCNP将NIR光转化为紫外光,从而实现980nm的NIR控制的PLK1基因沉默,将2-二乙烯键裂开.
在抗瘤治疗中观察到显著抑制瘤生长.

结论:

封装在UCNP中的纳米多重复合体T-si/UCNP可在瘤部位进行精确的NIR控制的siRNA释放,用于癌症RNAi治疗.
这种纳米聚合物增强了针对瘤的RNAi治疗的可控性和安全性.
该平台具有控制释放和激活其他治疗剂,如mRNA和DNA的潜力.

关键词:

通过NIR控制的siRNA释放.在UCNPs中,UCNPs是最重要的.这是一种抗瘤疗法.这是一个纳米多重复合体 (nanopolyplex).

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