长期腹的不寻常原因
Isairis Peralta1, Elizabeth Hubbard1, Laurentia Nodit1
1Pathology, University of Tennessee Medical Center/University of Tennessee Graduate School of Medicine, Knoxville, USA.
Cureus
|February 12, 2024
概括
科尔奇辛的毒性可能会导致严重的胃肠道问题,并且经常被忽视. 早期对科尔奇辛毒性的组织病理学诊断对于改善患者的结果至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
- 组织病理学 组织病理学
背景情况:
- 科尔奇辛是一种治疗指数狭窄的药物,经常用于各种疾病.
- 胃肠道症状是菌素治疗的常见副作用,发生在早期或长期使用时.
- 由于其高死亡率,如果不及时识别,非故意的菌素毒性是一个重大的临床问题.
研究的目的:
- 为了突出表明菌素毒性的基因病理学发现.
- 强调及时诊断的重要性,以改善科尔奇辛毒性病例患者的治疗结果.
- 介绍一个案例研究,说明诊断挑战和陈述菌素毒性.
主要方法:
- 一个77岁的女性出现脱水,慢性腹和体重减轻的病例报告.
- 对上下胃肠道进行内镜检查.
- 十二指肠活检的组织病理学分析.
主要成果:
- 内镜检查显示了胃腹膜中的红血性粘膜,还有其他不起眼的十二指肠和结肠.
- 十二指甲骨活检显示了部分状缩,延长的腺体,以及许多停止的环状线粒分裂.
- 这些基因病理学发现与菌素毒性一致.
结论:
- 组织病理学上识别colchicine毒性可能是具有挑战性的.
- 在十二指管活检中停止环状线粒瘤是胆固醇诱导肠道病变的关键指标.
- 及时识别和诊断菌素毒性对于患者的治疗和生存至关重要.
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