阻塞性睡眠呼吸暂停:一种导致痛风的因素
Pushti Khandwala1, Devashish Desai2, Mitali Sen3
1Rheumatology, Einstein Medical Center Philadelphia, Philadelphia, USA.
Cureus
|February 12, 2024
概括
肥胖和阻塞性睡眠呼吸暂停 (OSA) 显著增加痛风风险. OSA患者患上痛风的几率高出2.65倍,即使在与其他健康状况相匹配之后. 这突显了OSA和痛风之间的强烈联系.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 睡眠的药物 睡眠的药物
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与痛风具有共同的风险因素和病理生理机制,包括高尿血症.
- OSA和痛风之间的确切关系仍然是正在进行的研究和辩论的主题.
研究的目的:
- 研究肥胖患者中阻塞性睡眠呼吸暂停 (OSA) 和痛风之间的相关性.
- 为了量化与OSA相关的痛风风险增加,考虑共享的风险因素.
主要方法:
- 利用了电子医疗记录的TrinetX全球联合研究网络.
- 确定了BMI>30的患者,创建了具有和没有OSA的子组.
- 应用倾向性得分匹配 (PSM) 来控制年龄,性别,种族,CKD,心力衰竭和利尿剂的使用.
主要成果:
- 确定了3,541,566名肥胖患者;23.09%的人患有OSA.
- 患有OSA的患者患上痛风的患病率明显高 (7.19%对2.84%,p<0.0001).
- 在PSM之后,OSA仍然与痛风的几率增加1.53倍相关 (OR 1.533,p<0.0001).
结论:
- 痛风和阻塞性睡眠呼吸暂停 (OSA) 之间存在强烈的相关性.
- 慢性缺氧诱导的高尿血是将OSA与痛风联系起来的可能机制.
- 需要进一步的前性研究来证实这种关联的强度.
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