一个更新的系统审查和分析替代疗法对勃起功能和前列腺的影响
Zhunan Xu1, Xiangyu Chen2, Hang Zhou2
1Department of Urology, Tianjin Medical University General Hospital, Heping District, Tianjin, China.
Frontiers in endocrinology
|February 12, 2024
概括
替代疗法 (TRT) 改善了晚期出现的阴道腺乱症 (LOH) 的男性的勃起功能. 这次元分析发现TRT对前列腺健康是安全的,对IPSS,PV,Qmax,PVR或PSA没有任何不良影响.
科学领域:
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年病的医生 老年病的医生
背景情况:
- 与衰老相关的晚期发生的阴性腺体缺陷症 (LOH) 是常见的.
- 替代疗法 (TRT) 是对LOH的标准治疗方法.
- 对TRT的疗效和安全性进行了辩论.
研究的目的:
- 系统地审查和元分析TRT对LOH的有效性和安全性.
- 评估TRT对性功能和前列腺健康指标的影响.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了主要的数据库 (PubMed,Embase等) 从1990年到2023年. 从1990年到2023年.
- 包括28个RCT与3461名患者,分析各种TRT模式和持续时间.
主要成果:
- TRT显著改善了国际勃起功能指数 (IIEF) 的得分 (WMD 3.26,P<0.0001).
- 在国际前列腺症状评分 (IPSS),前列腺体积 (PV),最大流量率 (Qmax),空腔后残留尿量 (PVR) 或前列腺特异性抗原 (PSA) 方面,没有观察到TRT和安慰剂组之间的显著差异.
结论:
- TRT有效地改善了男性的性功能.
- 无论如何,TRT都不会对前列腺健康指标产生负面影响,无论使用何种方法或治疗持续时间.
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