儿童的非向代谢概况确定了喘和亚托皮的新途径
Stéphanie Lejeune1, Abhinav Kaushik2, Ella S Parsons3
1Department of Medicine, Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, Calif; University of Lille, Pediatric Pulmonology and Allergy Department, Hôpital Jeanne de Flandre, CHU Lille, Lille, France; University of Lille, INSERM Unit 1019, CNRS UMR 9017, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France.
喘和亚托皮显著改变了儿童的代谢概况. 综合条件 (喘和) 显示出最明显的变化,胆酸和脂质较高,聚氨酸较低.
科学领域:
- 儿科过敏和免疫学
- 代谢学 代谢学 代谢学
- 计算生物学 计算生物学
背景情况:
- 喘和亚托皮性疾病表现出不同的临床表型.
- 这些表型与不同的代谢概况和生物途径有关.
研究的目的:
- 为了确定与儿童中阿托皮和喘相关的独特代谢概况.
- 通过各种和喘组合来区分新陈代谢特征.
主要方法:
- 分析了470名儿童 (<13岁) 的血样本,分为四组:没有阿托皮/没有喘,只有阿托皮,只有喘,以及两者.
- 采用超高性能液态染色学-并联质谱仪用于非目标代谢分析.
- 采用机器学习分类器来识别歧视性代谢物.
主要成果:
- 鉴定了362种歧视性代谢物.
- 最显著的代谢差异在患有喘和阿托皮的儿童 (At+As+) 与没有任何 (At-As-) 的儿童之间观察到.
- 喘 (As+) 显示出比单独的阿托皮 (At+) 更明显的代谢变化.
结论:
- 喘和阿托皮综合表型 (At+As+) 具有明显的代谢特征.
- 这种特征表明改变了宿主-病原体相互作用,肠道微生物群和表观遗传修饰.
- 较低的抗氧化特性可能有助于在严重的喘中观察到的代谢特征.
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