在患有异常性CD4淋巴缺血症的人群中,对SARS-CoV-2mRNA疫苗接种的免疫反应
Joseph M Rocco1, Kristin L Boswell2, Elizabeth Laidlaw1
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
The Journal of allergy and clinical immunology
|February 12, 2024
概括
严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) mRNA疫苗在患有异常性CD4淋巴缺血症 (ICL) 的个体中显示出降低的免疫性,特别是那些CD4计数较低的人. 对于ICL患者,可能需要进一步剂量.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- SARS-CoV-2 mRNA 疫苗的免疫性在免疫受损的个体中是可变的.
- 缺少SARS-CoV-2 mRNA疫苗在异常性CD4淋巴缺血症 (ICL) 的免疫性数据.
研究的目的:
- 在ICL患者中确定SARS-CoV-2mRNA疫苗的免疫性.
- 在ICL患者中评估一系列CD4T细胞计数的疫苗反应.
主要方法:
- 在mRNA接种疫苗后,从25名ICL患者和23名健康志愿者 (HV) 收集了样本.
- 测量了抗尖峰和抗受体结合域抗体.
- 使用T细胞受体测序和刺激试验量化SARS-CoV-2特异性T细胞反应.
主要成果:
- 在接种了两次和三次疫苗后,ICL患者的抗尖峰IgG抗体水平低于HV患者.
- 在HV和ICL患者之间没有观察到抗体水平的显著差异,CD4计数>100细胞/微小L.
- 尖端特异性T细胞反应在ICL患者中不那么深刻,但CD4 T细胞激活和细胞因子产生没有显著差异.
结论:
- 具有CD4计数>100细胞/microL的ICL患者对SARS-CoV-2mRNA疫苗产生强大的免疫反应.
- 在ICL患者中,严重的CD4淋巴缺血导致疫苗诱导免疫力下降.
- 在ICL患者中,可能需要额外的疫苗剂量和降低风险的策略,这些患者患有严重的CD4淋巴缺血症.
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