在手术或保守管理的患有原发性副甲状腺功能障碍症的患者中,动脉内膜-介质厚度
Vincenzo Carnevale1, Flavia Pugliese2, Cristina Eller-Vainicher3
1Unit of Internal Medicine, "Casa Sollievo della Sofferenza" Hospital, IRCCS, 71013 San Giovanni Rotondo, FG, Italy.
The Journal of clinical endocrinology and metabolism
|February 12, 2024
概括
在一次性甲状腺功能障碍症 (PHPT) 中,副甲状腺切除术 (PTx) 可以在绝经后妇女中停止亚临床动脉样硬化进展. 保守管理显示动脉样硬化的恶化,表明PTx可能对心血管风险管理有益.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 手术研究的研究.
背景情况:
- 在原发性副甲状腺症 (PHPT) 中,心血管 (CV) 风险证据仍然不一致.
- 早期动脉样硬化评估对于管理PHPT患者的心血管风险至关重要.
研究的目的:
- 为了前性地研究早期动脉样硬化的变化.
- 在PHPT患者中比较副甲状腺切除术 (PTx) 和保守管理之间的结果.
主要方法:
- 评估了生物化学PHPT标记物,心血管风险因素,以及动脉内膜介质厚度 (IMT) 和斑块.
- 在基线和干预后≥24个月评估了52名绝经后PHPT患者 (PTx与非PTx).
主要成果:
- 在PTx后,PHPT标记物得到改善;保守管理显示甲状腺上腺激素增加.
- 在这两组人群中,静脉压和静脉压均增加;其他心血管风险因素没有变化.
- 在非PTx患者中,心动脉IMT显著增加,但在PTx患者中保持稳定.
结论:
- 副甲状腺切除术可以在绝经后的PHPT中阻止亚临床动脉样硬化进展.
- 保守的管理与随着时间的推移动脉硬化的恶化有关.
- 在PHPT中,PTx可能是一种减轻心血管风险的策略.
相关概念视频
Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...


