预防发病 - 我们还没有到达?
Matthias Koepp1,2, Eugen Trinka3,4, Wolfgang Löscher5,6
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology.
Current opinion in neurology
|February 12, 2024
概括
预防正在进步,超越症状管理,转向疾病修饰. 生物标志物正在启用预防获得性的临床试验,为患者提供新的希望.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 生物标志物研究 生物标志物研究
背景情况:
- 的治疗历史上一直专注于缓解症状.
- 对的疾病修饰或预防治疗的开发仍然是一个重要的未满足的需求.
研究的目的:
- 审查近期预防发病的进展.
- 探索在治疗中转向疾病预防的转变.
主要方法:
- 审查近期预防策略的进展情况.
- 对目标患者群体的生物标志物识别的分析.
- 检查正在进行的临床试验,以预防.
主要成果:
- 在使用EEG生物标志物治疗结核性硬化症的成功.
- 确定生物标志物,以丰富临床试验的患者群体.
- 临床试验的可行性和及时性,以预防获得的中枢神经系统攻击 (例如,TBI,中风,感染) 后的.
- 目前正在进行的两项试验的重点是预防中风后.
结论:
- 该领域正在进入治疗的时代,从症状管理转向疾病预防.
- 开发获得性的预防性治疗方法是一个关键的目标.
- 讨论了开发人类预防治疗的机会,挑战和解决方案.
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