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在 perfluorooctanesulfonyl化物生产工人的死亡率和癌症发病率

Bruce H Alexander¹, Andrew Ryan¹, Timothy R Church^1,2

¹Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.

American journal of industrial medicine

|February 12, 2024

概括

职业接触 perfluorooctanesulfonate (PFOS) 可能会增加脑血管疾病和膀癌的风险. 这项研究评估了暴露于PFOS的化学制造工人的死亡率和癌症发病率.

科学领域:

职业健康职业健康职业健康职业健康
环境毒理学环境毒理学
流行病学流行病学

背景情况:

和多基物质 (PFAS) 暴露与健康问题有关,但职业研究有限.
这项研究的重点是专用化学品制造业的工人暴露在化物中.

研究的目的:

为了评估暴露于化物 (PFOS) 的工人的死亡率和癌症发病率.
调查化学制造队列中累积PFOS暴露和健康结果之间的关系.

主要方法:

从1961年到2010年,建立了一个由4,045名工人组成的队列 (2,659名员工工作超过365天).
分析了死亡率数据 (至2014年) 和癌症登记数据 (1995-2014).
使用特定职位的甲硫酸盐 (PFOS) 等价物量化暴露,并使用统计模型 (SMR,Cox) 来评估风险.

主要成果:

在最高暴露四分位数中观察到脑血管疾病 (SMR=2.42) 和膀癌 (SMR=3.91) 的高死亡率.
在PFOS暴露和膀,结直肠和胰腺癌发病率之间发现了积极的关联.
肺癌显示出一个边界显著的关联 (HR=1.05).

结论:

职业PFOS暴露与脑血管疾病风险增加有关.
有证据表明,PFOS暴露与膀和肺癌发病率之间存在联系.
需要进一步的研究才能充分了解职业PFAS暴露对健康的长期影响.

关键词:

在PFAS中,我们可以使用PFAS.在PFOS系统中,我们可以癌症发生率癌症发生率死亡率死亡率通过和多基基物质.没有 perfluorooctanesulfonate 的情况.

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