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Updated: Jul 3, 2025

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
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Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence

Published on: February 10, 2023

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一群进化近期的KRAB指蛋白保护癌细胞免受复制性压力诱导的炎症

Filipe Martins1,2, Olga Rosspopoff1, Joana Carlevaro-Fita1

  • 1School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Cancer research
|February 12, 2024
PubMed
概括

某些KRAB指蛋白 (KZFP) 在癌症中被上调,通过抑制免疫反应促进瘤生长. 针对这些KZFP可能会提供新的癌症治疗策略.

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
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