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蒂奥芬 π-桥操纵NIR-II AIE基因用于多模式瘤光异常学

Yixiong Gui¹, Yuanwei Wang², Deliang Wang³

¹Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.

Angewandte Chemie (International ed. in English)

|February 12, 2024

概括

研究人员开发了一种单组分剂,用于同时进行癌症成像和治疗. 这种新型的聚合诱导发射光原体 (AIEgen) 对先进的光otheranostic应用非常有前途.

科学领域:

纳米技术纳米技术
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

开发用于同时成像和治疗的单组件多式联通光疗平台具有挑战性.
在第二个近红外窗口 (NIR-II) 中发射的聚合诱导发射光源 (AIEgens) 提供了更深层次的癌症治疗和增强治疗效能的潜力.
不同的 thiophene π 桥对 NIR-II AIEgens 的感觉行为的影响需要进一步调查.

研究的目的:

系统地研究NIR-II AIEgens与不同硫 π 桥梁的异能行为.
开发用于多式成像和协同癌症治疗的单组分治疗剂.
评估在临床前环境中开发的药物的疗效.

主要方法:

制造了一种新型AIEgen,BT-NS,其中包含一个[c]thiophene单元.
对NIR-II光,反应性氧物种 (ROS) 生成和光热转换效率的BT-NS的表征.
用于体内应用的BT-NS纳米颗粒的配方.
在瘤模型中评估NIR-II光,光声和光热成像引导的协同光动力学和光热疗法.

主要成果:

该BT-NS AIEgen表现出良好的NIR-II光,高效的ROS生成和高光热转换效率.
BT-NS纳米粒子展示了有效的多式成像能力 (NIR-II光,光声学,光热).
使用BT-NS纳米颗粒的协同光动力学和光热疗法实现了前所未有的瘤消除性能.

结论:

开发的基于[c]thiophene的AIEgen (BT-NS) 是一种有前途的单组分剂,用于多式联用光疗.
BT-NS纳米粒子通过联合光动力学和光热疗法实现有效的成像和协同的瘤消除.
这项研究为设计用于临床翻译的多功能光疗系统提供了宝贵的见解.

关键词:

在NIR-II光成像技术中使用NIR-II光成像技术.聚合引发的排放量聚合引发的排放量多式多种方式的光电异能学.π-桥梁工程桥梁工程

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