可注射的细胞外基质模拟液凝,基于电的Janus纤维
Jinzhong Zhang1, Xiaolong Zha2, Gengxin Liu3
1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. lszha@dhu.edu.cn.
Materials horizons
|February 12, 2024
概括
研究人员开发了一种可注射的ECM仿真水凝 (IEMH),模仿自然组织结构. 这种新的水凝支持细胞生长和营养物质的运输,显示生物医学应用的希望.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 现有的注射水凝无法复制纤维细胞外矩阵 (ECM) 架构.
- 缺乏ECM类微孔阻碍了当前水凝中的营养和废物运输.
- 这些局限性限制了可注射水凝在细胞生长和表型维持方面的生物疗效.
研究的目的:
- 制造一种可注射的ECM仿真水凝 (IEMH),克服当前生物材料的局限性.
- 创建一个具有自然ECM增强结构模仿的水凝.
- 开发一种适用于生物医学应用的水凝,需要容易的细胞相互作用和运输.
主要方法:
- 能够在体温下自我卷曲的Janus纤维被缩短和分散.
- 通过并排电和紫外线照射实现了IEMH的大规模生产.
- 描述包括SEM,TIRFM,NMR和FTIR来分析sol-gel过渡机制.
主要成果:
- IEMH在体温下证明了sol-gel过渡5重%的纤维,形成稳定,弹性和自我愈合的凝.
- 液凝表现出可取的伪塑性,用于室温注射.
- 鉴定证实了由于纤维纠和疏水相互作用的sol-gel过渡.
- 在体外细胞毒性测定显示,C2C12核细胞的细胞活力超过95%.
结论:
- 开发的IEMH成功地模仿了纤维ECM架构和微孔结构.
- 水凝具有出色的注射性,稳定性和自我愈合特性.
- IEMH显示出高生物相容性和各种生物医学应用的潜力.
相关概念视频
01:42The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
01:29The Extracellular Matrix
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...