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运动诱导的β-基酸盐促进Treg细胞分化,以改善小鼠的大肠炎

Fengqi Hao^1,2, Miaomiao Tian², Huiyue Wang²

¹School of Physical Education, Northeast Normal University, Changchun, Jilin, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

|February 12, 2024

概括

定期进行中度有氧运动 (RMAE) 可以通过代谢物β-基酸盐 (β-HB) 来预防性结肠炎 (UC). 这种运动诱导的β-HB促进调节性T (Treg) 细胞,减少炎症和减轻结肠炎.

科学领域:

运动生理学运动生理学
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

性结肠炎 (UC) 是一种慢性炎症性肠病,全球发病率正在上升.
众所周知,定期适度有氧运动 (RMAE) 可以降低UC风险和疾病严重程度.
根据RMAE对UC的有益影响的确切机制仍在调查中.

研究的目的:

为了研究β-基酸盐 (β-HB) 的作用,一个运动代谢物,在调解RMAE对大肠炎的保护作用.
阐明β-HB对免疫细胞群体的影响,特别是T辅助细胞17 (Th17) 和调节性T (Treg) 细胞,在结肠炎的背景下.

主要方法:

德克斯硫酸 (DSS) 诱导的小鼠结肠炎模型.
与RMAE预条件和β-HB补充/抑制的干预.
对结肠Th17/Treg细胞比率和Treg细胞分化标记物的分析 (例如,Foxp3).
在Treg细胞中评估组 histone 乙化和脂肪酸氧化.

主要成果:

RMAE预条件改善了DSS诱导的大肠炎,这种效果因阻断β-HB生产而受到损害,但通过β-HB补充物得到了挽救.
RMAE和β-HB治疗导致结肠Th17/Treg比率下降.
β-HB通过增强Foxp3表达通过基因素乙化和促进脂肪酸氧化直接促进Treg细胞分化.
单独给予β-HB,没有运动,在小鼠中缓解大肠炎.

结论:

运动代谢物β-HB在RMAE对大肠炎的抗炎作用中起着至关重要的作用.
β-HB促进Treg细胞的生成,有助于大肠炎的减弱.
准β-HB或增强Treg细胞功能是UC的潜在治疗策略.

关键词:

慢性炎症性疾病是一种慢性炎症性疾病.适度的有氧运动.监管性T细胞监管性T细胞性结肠炎是一种这是β-Hydroxybutyrate.

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