预防性药理疗法和复发性尿路结石疾病的风险
Kumaran Arivoli1, Autumn N Valicevic2, Mary K Oerline3
1University of Michigan School of Medicine, Ann Arbor, Michigan.
尿路结石疾病的预防性药理疗法与12-36个月内复发的风险降低有关,特别是对低酸的性治疗. 这一发现支持其用于治疗反复出现的尿路结石.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学 是一个学科.
背景情况:
- 尿路结石疾病的复发率很高,但由于证据有限,预防疗法未得到充分利用.
- 这项研究调查了药理干预措施在减少反复发生的尿路结石发作中的有效性.
研究的目的:
- 评估预防性药理疗法与临床上显著的尿路结石疾病复发之间的关联.
- 评估 thiazide 利尿剂,疗法和降尿酸药物对石头复发的影响.
主要方法:
- 对2012-2019年退伍军人卫生管理局数据的分析.
- 包括具有指数尿路结石事件和特定尿路异常 (高度尿,低度尿,高尿素尿) 的成年人.
- 考克斯比例危险回归以确定治疗和复发事件 (ED访问,住院,手术) 之间的关联.
主要成果:
- 预防性治疗与在12-36个月内出现复发性尿路结石的风险降低了19% (HR,0.81;P=0.0496).
- 在较长的随访期 (12-48个月和12-60个月) 中,有效性下降.
- 性治疗低位尿症显示,在12-36个月内,复发风险显著减少26% (HR,0.74;P=0.03).
结论:
- 预防性药理疗法与在12-36个月内减少临床显著的复发性尿路结石疾病有关.
- 性治疗低酸性尿症显示出与较低的复发风险有显著的关联.
- 研究结果支持使用预防性治疗,特别是性治疗,以治疗复发性尿路结石.
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