在HIV阳性患者中结核发病的时间及其预测因素:一项回顾性队列研究
Abraham Teka Ajema1, Yilkal Simachew1, Meiraf Daniel Meshesha2
1School of Public Health, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.
PloS one
|February 12, 2024
概括
人类免疫缺陷病毒 (HIV) 阳性患者中结核病 (TB) 的发病率仍然很高. 完成结核病预防疗法 (TPT) 和及时启动抗逆转录病毒疗法 (ART) 显著降低了结核病风险.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染显著增加结核病 (TB) 发展的风险.
- 有效管理艾滋病毒和结核病的共同感染需要了解结核病发病率及其预测因素在共同感染的个体.
研究的目的:
- 确定发生率和确定结核病 (TB) 在埃塞俄比亚哈瓦萨的人类免疫缺陷病毒 (HIV) 阳性患者的发展时间的预测因素.
- 在这个弱势群体中为结核病预防提供有针对性的干预措施的信息.
主要方法:
- 从2018年1月到2022年12月,对422名艾滋病毒阳性患者进行了回顾性队列研究.
- 使用Kaplan-Meier生存分析和Cox比例危险模型来评估无结核病生存率并确定风险因素.
- 使用Kobo工具箱从医疗记录中提取数据,并使用SPSS版本26.0.0进行分析.
主要成果:
- 在艾滋病毒阳性患者中,结核病的总发病率为每100人年6.26.
- 不完整的结核病预防疗法 (TPT) 与显著更高的结核病风险相关 (AHR = 6.2).
- 在连接一周内及时开始抗逆转录病毒疗法 (ART) (AHR = 0.44) 和更长的ART持续时间 (≥6个月) 与降低结核病风险有关.
结论:
- 埃塞俄比亚哈瓦萨的艾滋病毒阳性患者中结核病的发病率特别高.
- 确保完成TPT,优化ART启动和坚持,以及管理机会性感染对于降低结核病负担至关重要.
- 加强对TPT和ART保留的患者支持对于更好的健康结果至关重要.
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