血纤维素:在接受腹腔透析的患者中,左心室重塑的驱动因素及其相关风险因素
Yun Chen1, Shuqi Dai1, Xiaolin Ge1
1Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Renal failure
|February 12, 2024
概括
血纤维素的升高与腹腔透析患者的左心室缩进展有关. 高纤维素因子的危险因素包括年龄,高葡萄糖,胆固醇和hsCRP.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 生物化学 生物化学
背景情况:
- 血纤维素素是周周透析 (PD) 患者心血管死亡的已知危险因素.
- 在PD患者中,左心室 (LV) 改造和功能至关重要.
- 了解纤维素素在LV重塑中的作用对于控制心血管风险至关重要.
研究的目的:
- 为了研究血纤维素水平与左心室 (LV) 重塑和功能在PD患者之间的关联.
- 为了确定与该人群中纤维素素水平升高相关的危险因素.
主要方法:
- 招募了成人PD患者 (n=278),并跟踪了两年.
- 心声学评估了LV结构和功能;相关性和回归分析确定了相关性.
- 后勤回归和ROC曲线确定了纤维素素在LV缩 (LVH) 进展中的作用.
主要成果:
- 较高的纤维素水平与增加的 LV 质量指数 (LVMI),平均壁厚 (MWT) 和相对壁厚 (RWT) 相相关.
- 较高的E/A比率与纤维素原水平有负相关性.
- 纤维素原是LVH进展的独立风险因素;年龄,总胆固醇,禁食血糖和hsCRP与纤维素原水平较高有关.
结论:
- 血纤维素的升高与PD患者的LVH进展独立相关.
- 老年,更高的禁食血糖,总胆固醇和hsCRP是纤维素素水平升高的危险因素.
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