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对于MCMV特异性CD8+ T细胞的持久记忆反应,NFAT信号是不可或缺的

M Zeeshan Chaudhry1, Lisa Borkner1, Upasana Kulkarni1

  • 1Department of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

PLoS pathogens
|February 12, 2024
PubMed
概括

激活T细胞的核因子 (NFAT) 转录因子在潜伏期间对细胞巨乳病毒 (CMV) 特定的CD8+T细胞的长期膨胀至关重要. 消去NFATc1和NFATc2会影响T细胞成熟和病毒控制.

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