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Updated: Jul 3, 2025

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
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通过自动路径搜索微调G蛋白合受体的激活特异性

Rujuan Ti1, Bin Pang2, Leiye Yu2

  • 1Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.

Proceedings of the National Academy of Sciences of the United States of America
|February 12, 2024
PubMed
概括

我们开发了一个高效的模拟协议来预测分子相互作用,并设计选择性药物激动剂. 这种方法加速了对基-1-酸盐受体 (S1PRs) 新型化合物的发现.

关键词:
在GPCR中,GPCR是指GPCR.激活路径的激活路径设计的激进主义者设计.药物特异性的药物特异性斯芬戈-1-酸盐是一种酸盐.

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