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相关概念视频

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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相关实验视频

Updated: Jul 3, 2025

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
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体重过多是否会加速免疫衰老?

Anna Tylutka1, Barbara Morawin1, Łukasz Walas2

  • 1Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, Poland.

Experimental gerontology
|February 12, 2024
PubMed
概括

老年人多余的体重与改变的T淋巴细胞比例和免疫衰老有关. 人类测量指数和CD4/CD8比为预测老年人免疫衰老具有诊断价值.

科学领域:

  • 免疫学 免疫学 免疫学
  • 老年学是一门学科.
  • 肥胖问题研究研究

背景情况:

  • 超重和肥胖在老年人中维持慢性炎症,增强免疫力和增加并发症风险.
  • 这项研究研究了多余体质对T淋巴细胞分布的影响,以及人类指数和CD4/CD8比率在评估免疫衰老中的诊断效用.

研究的目的:

  • 为了确定多余的体重是否会影响老年人T淋巴细胞比例.
  • 评估人类指数和CD4/CD8比率的诊断用处,分析免疫衰变.

主要方法:

  • 103名年龄为73.6±3.1岁的个体根据BMI被分为正常 (18.5-24.9 kg/m2),肥胖前 (25.0-29.9 kg/m2) 和肥胖 (≥30.0 kg/m2) 的组.
  • 测量包括人体测量 (生物电阻),生物化学分析,T和B淋巴细胞计数 (流细胞测量),以及BAI,ABSI和LAP等指数.
  • 分析了数据,以评估体质,T淋巴细胞子集和免疫风险概况之间的关系.

主要成果:

  • 肥胖组的CD4+T细胞数量最高 (59.4%),CD8+T细胞数量最低 (31.6%).
  • 在前肥胖和肥胖组的20%以上观察到CD4/CD8比率>2.5,而在正常体重组的64.5%中<1个.
  • 身体肥胖指数 (BAI) 和脂质积累产品 (LAP) 在区分体质群体方面表现出高的诊断效用 (AUC~0.800-0.900).
关键词:
衰老的衰老 衰老的衰老CD4 - CD8 的比例是什么?免疫衰变的起源肥胖问题 肥胖问题的T淋巴细胞.

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结论:

  • 在正常与肥胖模型中的CD4 / CD8比率 (OR = 16.1) 表明与体重过重相关的免疫衰老的临床预后的诊断价值.
  • 结合CD4/CD8与BAI,LAP或ABSI,在肥胖的老年人和正常体重之间提供了很好的歧视 (AUC 0.865-1.00).