体重过多是否会加速免疫衰老?
Anna Tylutka1, Barbara Morawin1, Łukasz Walas2
1Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, Poland.
Experimental gerontology
|February 12, 2024
概括
老年人多余的体重与改变的T淋巴细胞比例和免疫衰老有关. 人类测量指数和CD4/CD8比为预测老年人免疫衰老具有诊断价值.
科学领域:
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
- 肥胖问题研究研究
背景情况:
- 超重和肥胖在老年人中维持慢性炎症,增强免疫力和增加并发症风险.
- 这项研究研究了多余体质对T淋巴细胞分布的影响,以及人类指数和CD4/CD8比率在评估免疫衰老中的诊断效用.
研究的目的:
- 为了确定多余的体重是否会影响老年人T淋巴细胞比例.
- 评估人类指数和CD4/CD8比率的诊断用处,分析免疫衰变.
主要方法:
- 103名年龄为73.6±3.1岁的个体根据BMI被分为正常 (18.5-24.9 kg/m2),肥胖前 (25.0-29.9 kg/m2) 和肥胖 (≥30.0 kg/m2) 的组.
- 测量包括人体测量 (生物电阻),生物化学分析,T和B淋巴细胞计数 (流细胞测量),以及BAI,ABSI和LAP等指数.
- 分析了数据,以评估体质,T淋巴细胞子集和免疫风险概况之间的关系.
主要成果:
- 肥胖组的CD4+T细胞数量最高 (59.4%),CD8+T细胞数量最低 (31.6%).
- 在前肥胖和肥胖组的20%以上观察到CD4/CD8比率>2.5,而在正常体重组的64.5%中<1个.
- 身体肥胖指数 (BAI) 和脂质积累产品 (LAP) 在区分体质群体方面表现出高的诊断效用 (AUC~0.800-0.900).
结论:
- 在正常与肥胖模型中的CD4 / CD8比率 (OR = 16.1) 表明与体重过重相关的免疫衰老的临床预后的诊断价值.
- 结合CD4/CD8与BAI,LAP或ABSI,在肥胖的老年人和正常体重之间提供了很好的歧视 (AUC 0.865-1.00).
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