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通过iRGD调解的pH响应的半孔酸盐增强了瘤中药物的积累

Xiaoning Wang¹, Yangguang Zhao², Mengru Yan²

¹College of Pharmacy, Xi'an Medical University, Xi'an, Shaanxi 710021, PR China; The School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, PR China.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

|February 12, 2024

概括

这项研究引入了一种新型的双重修饰的半孔氧化纳米载体,用于三阴性乳腺癌. 该iRGD和pH响应性聚合物增强瘤透和药物释放,显著抑制瘤生长,毒性最小.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
在瘤学瘤学.

背景情况:

有限的纳米载体透率和缓慢的药物释放阻碍了癌症治疗.
针对特定的受体,如αvβ3整合素和NRP-1,对于有效的药物输送至关重要.

研究的目的:

开发一种新型的双修饰的半孔氧化纳米载体,用于三阴性乳腺癌治疗.
为了增强瘤透,并实现pH响应的药物释放,以提高治疗疗效.

主要方法:

用iRGD和聚二乙烯二氧化 (PEOz) 修改了半孔的纳米载体.
在体外研究中评估了受体结合,细胞吸收,药物释放动力学,细胞毒性和瘤球状透.
在体内研究评估了裸体小鼠模型中的瘤生长抑制和全身毒性.

主要成果:

这种双重修饰的载体选择性地准了αvβ3整体蛋白,并通过NRP-1透到瘤中.
PEOz的修改使得pH依赖,药物快速释放和有效的溶酶体逃逸.
iRGD功能化增强了NRP-1-阳性癌细胞中的细胞吸收和细胞毒性.
在体内研究显示显著的瘤生长抑制没有观察到系统性毒性.

结论:

双修饰的半孔氧化纳米载体提供增强的瘤透和向药物输送.
这种新的系统显示了改善三阴性乳腺癌治疗的巨大潜力.
iRGD和PEOz修改代表了高级癌症纳米治疗的有希望的战略.

关键词:

半孔的二氧化.聚二乙烯二氧化) 是一种聚二乙烯二氧化.三阴性乳腺癌是三阴性乳腺癌.iRGDD 是一个很好的方法.

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