2型糖尿病患者的炎症生物标志物与死亡率之间的关联:NHANES 2005-2018年
Jiaqi Zhang1, Xiaoting Fan1, Yan Xu1
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, Jilin 130021, China.
Diabetes research and clinical practice
|February 12, 2024
概括
包括NLR和SIRI在内的炎症生物标志物增加与美国糖尿病成年人死亡风险增加有关. 这些标记物的较高水平显著预测了全因和心脑血管疾病死亡率.
科学领域:
- 心血管疾病流行病学
- 糖尿病研究研究 糖尿病研究
- 炎症和死亡率的不同.
背景情况:
- 糖尿病是心血管疾病和死亡率的重要危险因素.
- 炎症过程在糖尿病并发症的发病过程中起着至关重要的作用.
- 确定可靠的生物标志物对于糖尿病人群中死亡风险分层是必不可少的.
研究的目的:
- 调查各种炎症生物标志物与全因死亡率之间的独立关联.
- 检查这些生物标志物与心脑血管疾病 (CCD) 死亡率在美国成年糖尿病患者之间的关系.
主要方法:
- 分析了6412名20岁及以上的美国糖尿病成年人的队列.
- 数据被跟踪到2019年12月31日.
- 考克斯比例危险模型和卡普兰-梅尔生存曲线被用来评估与炎症生物标志物相关的死亡风险.
主要成果:
- 炎症生物标志物的最高四分位数,包括中性细胞与淋巴细胞比率 (NLR),单细胞与淋巴细胞比率 (MLR),系统免疫炎症指数 (SII),系统炎症反应指数 (SIRI) 等,显示出与全因死亡率的积极关联.
- 卡普兰-梅尔生存分析显示,高于特定值的炎症生物标志物水平与所有原因和CCD死亡率的显着更高风险相关 (Log排名P <0.05).
结论:
- 几种炎症生物标志物,如NLR,MLR,SII,SIRI等,与美国糖尿病成年人全因和CCD死亡率的增加显著相关.
- 对于这些生物标志物,存在一个关键值,超过这个值,死亡风险会大幅增加.
- 这些发现突显了炎症生物标志物的潜力,用于糖尿病患者的风险评估.
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