血液金属与成年人焦虑的关联:全国代表性的横截面研究
Kaiju Chen1, Meitao Tan1, Ying Li1
1Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, PR China.
Journal of affective disorders
|February 12, 2024
概括
(Cd) 暴露与焦虑有关,特别是在目前的吸烟者中. 混合金属暴露也增加了焦虑的风险,是主要的贡献者.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 关于金属暴露与焦虑之间的关联,存在不一致的证据.
- 了解 (Pb), (Cd), (Hg), (Se) 和 (Mn) 等特定金属对焦虑的影响至关重要.
研究的目的:
- 研究血液金属 (Pb,Cd,Hg,Se,Mn) 对一般人群焦虑的单独和综合影响.
- 探索吸烟状态如何改变金属暴露和焦虑之间的关系.
主要方法:
- 利用了来自2011-2012年国家健康和营养检查调查 (NHANES) 4000名参与者的数据 (年龄≥20岁).
- 采用多重后勤回归,受限立方线 (RCS) 的后勤分析和加权量子总和 (WQS) 的回归.
- 根据吸烟群体进行了分层分析.
主要成果:
- 总的来说,血中Pb,Cd,Hg,Se和Mn的水平与焦虑没有显著的关联.
- 然而,血液中的 (Cd) 与目前吸烟者的焦虑有积极的关联 (OR: 1.708,95% CI: 1.063-3.040).
- WQS回归表明,混合金属暴露与焦虑有积极的关联 (OR:1.437,95% CI:1.031-2.003),其中Cd贡献了最大的权重.
结论:
- 增加的 (Cd) 暴露被确定为焦虑的重要危险因素.
- 对多种金属 (Pb,Cd,Hg,Se,Mn) 的同时暴露与焦虑风险有关,特别是在目前的吸烟者中.
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