[针对晚期甲状腺癌的全身疗法 - 更新]
Tim Brandenburg1,2, Yara Maria Machlah1,2, Dagmar Führer-Sakel1,2
1Klinik für Endokrinologie, Diabetologie und Stoffwechsel, Universitätsklinikum Essen, Essen, Germany.
Laryngo- rhino- otologie
|February 12, 2024
概括
四种多酶抑制剂 (MKI) 在德国治疗晚期甲状腺癌. 最近的批准包括Cabozantinib用于放射性耐火DTC和Selpercatinib用于MTC和DTC,提供新的治疗选择.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 在德国,四种多酶抑制剂 (MKIs) 已被批准用于治疗进展性放射性耐火的分化甲状腺癌 (rrDTC) 和髓性甲状腺癌 (MTC).
- 卡博桑提尼布最近获得批准,作为基于COSMIC-311试验的高级rrdTC的二线治疗.
- 作为一种选择性RET抑制剂的塞尔珀卡丁尼布,在具有RET变化的高级MTC和rrDTC中表现出有效性.
研究的目的:
- 要总结最近在治疗晚期甲状腺癌 (ATC) 的进展.
- 突出ATC的新疗法选择和指导方针变化.
- 在甲状腺癌治疗中提供已批准的多酶抑制剂和新药的概述.
主要方法:
- 对III期临床试验和最新试验数据的审查 (例如,COSMIC-311).
- 对 rrDTC 和 MTC 已批准的多酶抑制剂 (MKI) 的分析.
- 在先进的MTC和 rrDTC中评估Selpercatinib的疗效和安全性.
主要成果:
- 卡博赞提尼布已被批准作为高级rrdtc的二线治疗.
- 塞尔珀卡提尼布在一线高级MTC (RET突变) 和二线 rrDTC (RET融合) 中显示出有希望的疗效和有利的副作用概况.
- 当前的ATA指南反映了空中交通管制处理的变化和新方法.
结论:
- 晚期甲状腺癌的治疗领域随着新的MKI批准和Selpercatinib等新型药物而扩大.
- 包括RET抑制剂在内的向疗法为特定的MTC和rrDTC患者群体提供了更好的结果.
- 更新的临床指南将这些进展纳入其中,指导ATC的治疗决策.
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