双相情感障碍中的血清 Galectin-1, Galectin-9 和 YKL-40 水平及其与认知功能的关系
Elcicek Selahaddin1, Demir Bahadir1, Sahin Sengul1
1Faculty of Medicine, Department of Psychiatry, Gaziantep University, Gaziantep, Turkey.
Brain and behavior
|February 12, 2024
概括
双相情感障碍患者中低水平的加列-1,加列-9和YKL-40与认知功能受损相关,这表明这些生物标志物在神经炎症中具有潜在的神经保护作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 神经炎症越来越多地与双相情感障碍的病原发生有关.
- 特定的生物标志物,如Galectin-1,Galectin-9和YKL-40,正在研究它们在神经炎症和情绪障碍中的作用.
研究的目的:
- 在患有双相情感障碍的患者中检查了galactin-1,galectin-9和ykl-40的血清水平.
- 检查这些生物标志物水平和双相情感障碍的认知功能之间的关系.
主要方法:
- 来自64名情绪双重症患者和64名健康对照者的血清样本使用ELISA分析了galactin-1,galectin-9和YKL-40水平.
- 使用Stroop测试和Trail-Making测试来评估认知功能.
主要成果:
- 与健康对照组相比,患有双相情感障碍的患者表现出与健康对照组相比,galactin-1,galectin-9,ykl-40的血清水平显著降低.
- 双极性患者在Stroop和Trail-making测试中得分明显更高,表明认知表现较差.
- 在所有参与者中,这些生物标志物的血清水平与认知表现之间观察到微弱的正相关性.
结论:
- 在双相情感障碍患者中降低了加列-1,加列-9和YKL-40的水平,表明它们与神经炎症有关.
- 这些发现表明双相情感障碍患者的认知功能受损.
- 积极的相关性表明,加勒-1,加勒-9和YKL-40的潜在神经保护作用,这就需要在这个尚未探索的领域进行进一步的研究.
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