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用健康马的蒙特卡洛模拟来确定斯福米的药理动力学/药理动力学切断值

Taisuke Kuroda¹, Yohei Minamijima², Hidekazu Niwa³

¹Clinical Veterinary Medicine Division, Equine Research Institute, Japan Racing Association, Tochigi, Japan.

The Journal of veterinary medical science

|February 12, 2024

概括

斯福米辛 (FOM) 的临床断点 (CBP) 在动物中未定义. 这项研究确定了马匹的FOM PK/PD切线,建立了抗菌感应测试 (AST) 的CBP,以指导有效的大肠杆菌治疗.

科学领域:

兽医药理学兽医药理学
抗微生物耐药性抗微生物耐药性
药理动力学/药理动力学

背景情况:

菌素 (FOM) 在日本已被批准用于大型动物,但在兽医中缺乏用于抗微生物敏感性测试 (AST) 的定义临床断点 (CBP).
建立CBP对于指导适当使用抗生素和打击抗菌素耐药性至关重要.

研究的目的:

为了确定马中的斯福米辛 (FOM) 的药理动力学/药理动力学 (PK/PD) 截止值.
建立在马医学中进行抗菌素敏感性测试 (AST) 的临床断点 (CBP) 的基础.

主要方法:

在静脉注射 (IV) 20 mg/kg体重 (BW) FOM后,分析了九匹马的药理动力学 (PK) 数据.
使用非线性混合效应建模和蒙特卡洛模拟来确定PK/PD目标的实现.
应用了PK/PD目标,即自由血度-时间曲线下的面积除以最小抑制度 (MIC) >24小时.

主要成果:

每12小时 (q12小时) 输入一次的FOM20 mg/kg的PK/PD切线值估计为≤16.0 mg/L的MIC值.
预计这种剂量方案在健康马匹中对大肠杆菌 (MIC₉₀ = 16.0 mg/L) 有效.

结论:

这项研究为马的FOM提供了PK/PD衍生的切断值,支持建立AST的CBP.
兽医可以使用FOM 20 mg/kg BW q12 hr IV用于*E. coli*感染,MIC <16 μg/mL,考虑到FOM在人类医学中的重要性.

关键词:

埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.对抗微生物的敏感性测试.这种药物是斯福米辛 (phosfomycin).马的马,马的马,马的马,马的马.药理动力学/药理动力学 (PK/PD) 截止时间

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