前垂体的发育:干细胞/祖细胞的多种血统
1Institute for Endocrinology, Meiji University, Kanagawa 214-8571, Japan.
Endocrine journal
|February 12, 2024
概括
垂体发育涉及多种细胞起源,SOX2阳性干细胞形成所有内分泌细胞类型. 产后垂体组织是来自各种胚胎起源的细胞的马赛克,包括S100β阳性原生细胞.
科学领域:
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- pituitary 腺体,对于激素调节至关重要,包括腺和神经,起源于不同的胚胎组织.
- pituitary内分泌细胞分化的研究在1988年发现PIT1转录因子后取得了重大进展.
- 最近的发现强调SOX2阳性干细胞/原始细胞是所有垂体内分泌细胞类型的来源.
研究的目的:
- 为了提供对垂体腺发育的最新概述.
- 阐明垂体内分泌细胞的起源和分化途径.
- 为了澄清干细胞/祖先细胞在产后垂体组织中的作用.
主要方法:
- 对近期关于 pituitary 发育和细胞分化的文献的综述.
- 在早期胚胎中使用特定标记基因进行血统追踪研究的分析.
- 在垂体干细胞/原生细胞中检查分子标记物,包括SOX2和S100β.
主要成果:
- 前 pituitary 由adenohypophyseal placodal 细胞发展,并结合神经和外皮衍生的细胞,形成一个马赛克.
- 产后垂体组织含有干细胞/原始细胞,通常在辅体内形成集群.
- S100β阳性细胞被确定为产后垂体干细胞/原始细胞的重要组成部分.
结论:
- 下垂体发育是一个复杂的过程,涉及来自多个胚胎起源的贡献.
- 阳性SOX2干细胞对于产生多样化的内分泌细胞群的基因组至关重要.
- 了解垂体细胞的异质性和起源,包括S100β阳性细胞,是了解垂体功能和发育的关键.
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