在诊断和治疗膀癌的进展
Antonio Lopez-Beltran1, Michael S Cookson2, Brendan J Guercio3
1Department of Morphological Sciences, Unit of Anatomic Pathology, University of Cordoba Medical School, Cordoba, Spain em1lobea@gmail.com liang_cheng@yahoo.com.
BMJ (Clinical research ed.)
|February 12, 2024
概括
膀癌的治疗方法正在进步,新的疗法对非肌肉侵入性膀癌 (NMIBC) 和肌肉侵入性膀癌 (MIBC) 都显示出前景. 确定最佳的患者选择标准对于改善结果至关重要.
科学领域:
- 尿瘤学 尿瘤学
- 癌症基因组学 癌症基因组学
- 免疫治疗是一种免疫疗法.
背景情况:
- 膀癌是一个重要的全球健康问题,影响生活质量和医疗保健成本.
- 大型出血症通常是膀癌诊断的信号.
- 目前的治疗方法为非肌肉侵入性膀癌 (NMIBC) 和肌肉侵入性膀癌 (MIBC) 提供了不同的生存率.
研究的目的:
- 审查NMIBC和MIBC的当前和新兴治疗策略.
- 突出分子亚型在治疗反应中的重要性.
- 强调需要改进患者选择标准的需要.
主要方法:
- 对NMIBC和MIBC当前临床管理的审查.
- 分析了"癌症基因组图谱"项目的研究结果.
- 讨论新的治疗方法,包括免疫疗法,基因疗法和向治疗.
主要成果:
- NMIBC的管理包括通过尿道切除 (TURBT) 和静脉内疗法 (IVe),免疫疗法 (BCG) 作为黄金标准.
- MIBC研究发现了影响治疗反应的独特分子亚型.
- 对转移性疾病的新兴治疗方法包括免疫检查点抑制剂和抗体药物联合体.
结论:
- 在膀癌治疗方面取得了重大进展,特别是免疫疗法和向疗法.
- 了解膀癌的异质性是个性化治疗的关键.
- 需要进一步的研究来确定最佳治疗效益的患者选择标准.
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