在1.5T磁共振成像扫描上对肝胆功能进行评估,通过T1减速评估使用可变翻转角度序列进行T1减速评估
Marco Di Stasio1, Cesare Cordopatri1, Cosimo Nardi1
1From the Department of Experimental and Clinical Biomedical Sciences, University of Florence-Azienda Ospedaliero-Universitaria Careggi.
Journal of computer assisted tomography
|February 12, 2024
概括
这项研究开发了一种新的MR T1放松计工具,用于评估肝胆功能. 该方法在体外和体内准确地测量T1减少率 (T1RR),在肝硬化肝脏中显示出高可靠性.
科学领域:
- 放射学 放射学是一门学科.
- 定量成像技术 定量成像技术
- 医学物理 医学物理
背景情况:
- 磁共振 (MR) 放松计提供了对肝脏胆道功能的定量评估.
- T1减小率 (T1RR) 是一种可重现的指标,系统误差低于传统的T1测量.
- 加多乙氧-乙烯氨酸是用于肝脏成像的对比剂.
研究的目的:
- 开发和验证一个MR T1放松计工具用于肝脏T1RR评估.
- 在1.5T MR系统上评估开发工具的准确性和可靠性.
- 将工具的性能与标准化商业方法进行比较.
主要方法:
- 在体外和体外肝脏T1RR使用两个3D FLASH可变翻角序列和MATLAB算法计算.
- 前性研究包括13名正常肝脏和26名肝硬化肝脏.
- ImageJ软件用于感兴趣地区的测量;使用IBM-SPSS统计进行统计分析.
主要成果:
- 该方法在体外表现出了良好的准确性,最大误差为9%.
- 建议方法与商业工具之间观察到很高的一致性 (P < 0.05).
- 肝硬化患者的T1RR中位数为74.8 (正常),67.9 (Child-Pugh A) 和52.1 (Child-Pugh B). 读者内部和读者间的可靠性很高 (ICC 0.85-0.95).
结论:
- 开发的MR T1放松计工具提供了肝胆功能准确可靠的体外/体外评估.
- 该方法适用于在加多乙基基-二乙二胺五酸注射后评估肝脏T1RR.
- 这种定量方法提高了肝病评估的诊断能力.
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