同伴性对操作体的不同影响 响应社会互动和状多巴胺活动
Jonathan J Chow1, Kayla M Pitts2, Ansel Schoenbaum2
1Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21230 jonathan.chow@nih.gov yavin.shaham@nih.gov.
概括
老鼠更喜欢社交互动而不是药物,但同行性关系很重要. 大脑中的多巴胺活动反映了这些取决于性别的社会选择,独立于雌性老鼠的雌性周期.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 动物模型 动物模型
背景情况:
- 在老鼠中,社交互动是一种强大的强化剂,与药物相当.
- 之前关于社会操作员行为的研究仅使用了同性同龄人.
- 同龄人性和女性雌性周期对社会强化的影响尚不清楚.
研究的目的:
- 为了调查同行性是否影响大鼠的操作性社会互动.
- 确定雌性循环和条状多巴胺在同性与异性社会相互作用中的作用.
- 在社会互动期间检查核accumbens核心和dorsomedial条纹体中的性别特异性多巴胺信号传递.
主要方法:
- 在固定比例1计划下,鼠被杆压迫进入同性或异性同龄人.
- 在整个研究过程中,女性的雌性周期都受到监测.
- 基因编码的多巴胺传感器 (GRAB-DA2m) 用于测量核中核中核和背中状体中多巴胺释放.
- 通过操纵响应要求来评估对社会互动的经济需求.
主要成果:
- 与同性同龄人相比,雄性大鼠对异性同龄人有更高的操作反应.
- 雌性大鼠在基于同龄人的性别的操作反应中没有差异.
- 女性的雌性周期并没有显著影响操作者的社会互动.
- 排性多巴胺信号取决于同龄人的性别和特定的大脑区域 (核心核与背中状体).
结论:
- 同龄人之间的性行为显著影响了操作者的社交互动,特别是在雄性大鼠中.
- 女性的雌性周期似乎没有调节社会互动的强化特性.
- 核中核中的多巴胺活性和背中介质条纹体编码了取决于性别的意志社会相互作用的方面.
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