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基因预测的酒精消费对子宫内膜癌症风险的因果关系从孟德尔的随机化研究

Jie Yang¹, Xiang Qu¹, An-Jie Zheng¹

¹Department of Oncology, Baoji Gaoxin Hospital, No.19, Gaoxin 4 Road, Gaoxin District, Baoji, 721000, Shaanxi Province, China.

Scientific reports

|February 12, 2024

概括

基因预测的酒精消费显示出对子宫内膜癌 (EC) 的保护作用,特别是对子宫内膜癌 (EC) 的保护作用. 这一发现表明,酒精可能会降低EC风险,可能是通过降低人体胆管激素和胰岛素样生长因子1水平.

科学领域:

妇科瘤学妇科瘤学
癌症流行病学癌症流行病学
遗传流行病学遗传流行病学

背景情况:

子宫内膜癌 (EC) 发病率正在上升,在观察性研究中与酒精消费有不一致的联系.
门德尔随机化 (MR) 分析可以克服混因素,并在流行病学研究中逆转因果关系.
调查酒精摄入量与EC风险之间的因果关系对于公共卫生至关重要.

研究的目的:

用两个样本的孟德尔随机化分析来确定酒精消费对子宫内膜癌风险的因果关系.
探索任何观察到的因果作用的潜在调解途径,如激素水平.
区分酒精对不同类型子宫内膜癌亚型的影响.

主要方法:

利用了来自大型全基因组关联研究 (GWAS) 的总结级数据,用于酒精暴露和EC.
采用了57个单核酸多态 (SNPs) 作为基因预测酒精消费的仪器变量.
应用逆方差加权 (IVW) 方法作为主要分析,用MR-Egger回归和加权中位数作为灵敏度分析.

主要成果:

基因预测较高的酒精消费与EC风险显著降低有关 (OR=0.57,P<0.001).
酒精消费显示出对子宫内膜腺癌 (EEC) 具有保护作用 (OR=0.56,P=0.004),但对非子宫内膜腺癌 (EC) 没有保护作用.
酒精摄入量与人类胆性淋巴激素 (HCG) 和胰岛素样生长因子1 (IGF1) 的水平降低相关.

结论:

基因预测的酒精消费作为子宫内膜癌的保护因素,特别是EEC亚型.
保护机制可能包括降低HCG和IGF1水平.
MR 分析为因果关系提供了强有力的证据,加强了传统流行病学研究之外的发现.

关键词:

酒精消费酒精消费酒精消费因果推理的原因推理.这是子宫内膜癌的癌症.门德尔的随机化保护因素保护因素

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