脊椎骨关节炎是绝经后妇女脊椎骨折的风险之一
Tatsuhiko Kuroda1, Masataka Shiraki2, Mitsuru Saito3
1Public Health Research Foundation, Shinjuku-ku, Tokyo, Japan.
Scientific reports
|February 12, 2024
概括
脊椎骨关节炎 (OA) 增加了脊椎骨折的风险,即使有高骨矿物质密度 (BMD). 这一发现凸显了脊椎骨质炎作为绝经后妇女骨折预测的关键因素.
科学领域:
- 整形外科 整形外科 整形外科
- 老年学是一门学科.
- 放射学 放射学是一门学科.
背景情况:
- 骨关节炎 (OA) 越来越被认为是骨质疏松性骨折的危险因素,尽管与高骨矿物质密度 (BMD) 有关.
- 脊椎骨质炎和脊椎骨折之间的特定联系仍未得到充分研究.
研究的目的:
- 调查脊柱骨关节炎与日本绝经后妇女脊椎骨折的发生率之间的关系.
- 为了确定脊柱骨关节炎是否是脊椎骨折的独立风险因素,无论骨质量水平如何.
主要方法:
- 对一组日本绝经后妇女的纵向分析.
- 使用Kellgren-Lawrence分级诊断的脊柱OA;通过半定量X射线分析评估的脊椎骨折.
- 考克斯回归分析和ROC分析被用于评估风险和骨损伤值.
主要成果:
- 脊椎骨质炎 (≥2级) 是发生脊椎骨折的显著预测因素 (HR,1.52;95% CI:1.19-1.93,p=0.001).
- 确定了骨折风险的明显的腰椎骨质量值:脊椎骨质炎患者的0.952 g/cm2,没有脊椎骨炎患者的0.753 g/cm2.
- 这项研究对1480名女性进行了8.1±6.4年的跟踪,观察了923名脊柱骨关节炎和473名发生脊椎骨折的女性.
结论:
- 脊柱骨关节炎的存在是发生脊椎骨折的独立风险因素.
- 在骨折风险评估中应考虑脊柱骨折,特别是在绝经后的妇女中,即使骨质量看起来很高,也应该考虑脊柱骨折.
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