相关实验视频
Updated: Jun 10, 2026

07:58
Cell-Free DNA Integrity Analysis in Urine Samples
Published on: January 5, 2017
13.8K
通过目标尿液挥发性有机化合物生物传感器平台检测尿道癌症
Vichayut Suthat Na Ayutaya1, Chaianan Tantisatirapoon2, Sekdusit Aekgawong2
1School of Internal Medicine, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Scientific reports
|February 12, 2024
概括
尿液中的挥发性有机化合物 (VOC) 显示出对非侵入性泌尿生殖系统癌症检测的前景. 特定的VOC如甲和乙醇,由金属氧化物生物传感器检测,可以显著预测癌症的存在.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 在瘤学瘤学.
背景情况:
- 挥发性有机化合物 (VOC) 在非侵入性癌症诊断方面越来越重要.
- 金属氧化物生物传感器平台为检测尿液等生物样本中的VOC提供了一个有希望的途径.
研究的目的:
- 评估一个金属氧化物生物传感器平台的可行性,用于使用尿液VOC检测生殖尿路癌症.
- 为了确定特定的VOC生物标志物,表明生殖尿道恶性瘤.
主要方法:
- 利用五个商业半导体传感器检测尿样中的各种VOC.
- 在2000mV加热器电压下分析了与VOC代谢相关的电阻变化.
- 使用后勤回归和接收器运行特征 (ROC) 分析来评估生物标志物.
主要成果:
- 甲,异,和乙醇的VOC显示出对生殖尿道癌的显著预测能力 (P=0.013).
- ROC分析证实了这些VOC在疾病预测中的统计意义 (P<0.05).
- 这项研究包括64名参与者:32名尿生殖系统癌症患者和32名对照患者.
结论:
- 尿液中的甲,异,和乙醇显示出作为尿生殖系统癌症诊断的生物标志物的潜力.
- 开发针对这些VOC的向性气体金属氧化物传感器可能会导致创新的,非侵入性的癌症检测工具.
相关概念视频
Urine Studies I: Urinalysis
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
Urine Studies II: Urine Culture and Sensitivity Test
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
Microbial Biosensors
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

