在患有炎症性肠病的青少年患者中发生心房的风险
Doaa El Amrousy1, Heba El Ashry2, Sara Maher3
1Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt. doaa.moha@med.tanta.edu.eg.
European journal of pediatrics
|February 12, 2024
概括
患有炎症性肠病 (IBD) 的儿科患者表现出长时间的心房电机延迟 (EMD),这是心房动 (AF) 的早期标志物. 这表明这些年轻人患有AF的风险增加.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
背景情况:
- 慢性炎症越来越多地与心房 (AF) 的开始和进展有关.
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),是具有多种表现的全身炎症状况.
- 耳前电机延迟 (EMD) 被认为是AF的早期指标.
研究的目的:
- 评估在缓解期间患有IBD的儿童和青少年的心房电机特性.
- 调查IBD亚型 (CD和UC) 和健康对照之间的心房EMD的潜在差异.
主要方法:
- 该研究包括100名IBD患者 (50名CD,50名UC),年龄在12-17岁,处于缓解期,以及100名健康对照.
- 房电力学特性被评估使用跨胸腔心声学,组织多普勒成像和同时表面心电图.
- 计算的关键指标包括心室间EMD,左心室内EMD和右心室内EMD.
主要成果:
- 与健康对照组相比,缓解期的IBD患者表现出明显延长的左心室内EMD,右心室内EMD和心室内EMD (P=0.03,P=0.02,P=0.01).
- 在CD和UC患者组之间,没有发现心房间间和心房内EMD的统计学上显著差异.
结论:
- 在儿科IBD患者中心房EMD升高表明患有AF的风险增加.
- 测量心房EMD参数可以作为儿童IBD患者AF风险的预测工具.
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