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类似胰岛素的增长因子-I的调解作用,是维生素D和妊娠期糖尿病之间的联系的基础

Lingling Cui¹, Zhiqian Li¹, Xiaoli Yang¹

¹Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.

Reproductive sciences (Thousand Oaks, Calif.)

|February 12, 2024

概括

较低的维生素D (25(OH) D3) 水平和较高的胰岛素样生长因子-I (IGF-I) 会增加妊娠糖尿病 (GDM) 的风险. IGF-I可能会调解维生素D和GDM之间的联系.

科学领域:

内分泌学在内分泌学.
孕产妇和胎儿医学孕产妇和胎儿医学
营养科学营养科学

背景情况:

维生素D缺乏与妊娠期糖尿病 (GDM) 有关.
胰岛素样生长因子-I (IGF-I) 与维生素D和GDM有关.
需要进一步调查25(OH) D3,IGF-I和GDM风险之间的相互作用.

研究的目的:

检查血清25(OH) D3和IGF-I与GDM风险的独立和联合关联.
调查IGF-I在25(OH) D3和GDM之间的关系中的潜在调解作用.
澄清这些生物标志物在怀孕期间GDM发育中的作用.

主要方法:

对278名孕妇 (125例GDM病例,153例对照) 的前性队列研究.
测量母亲的血清25(OH) D3和IGF-I在怀孕的第二个三个月.
后勤回归和调解分析,以评估关联和调解效应.

主要成果:

较高的25[OH]D3四分位数与降低GDM风险相关 (OR < 1).
血清IGF-I的较高四分位数与增加的GDM风险 (OR > 1) 有显著的关联.
IGF-I介导了25(OH) D3和GDM之间约19.62%的关联.

结论:

较低的血清25(OH) D3度和较高的血清IGF-I度在第二个三个月内与增加的GDM风险有关.
血清IGF-I可能起到调解作用,部分解释了维生素D状态和GDM之间的关系.
这些发现强调了怀孕期间监测维生素D和IGF-I水平对于预防GDM的重要性.

关键词:

孕期糖尿病是一种糖尿病.胰岛素类生长因子-I 调解效应调解效应是一种调解效应.维生素D 维生素D是一种维生素.

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