代谢综合征和围尿道前列腺纤维化之间的相关性:前性研究结果
Jingwen Ren1,2, Yuanyuan Li1,3, Xueyuan Zhang4
1Department of Urology, Guizhou Provincial People's Hospital, Guiyang, China.
BMC urology
|February 12, 2024
概括
前列腺纤维化与下泌尿道症状有关,在有代谢综合征 (MetS) 的男性中明显更广泛. 肥胖和高血糖等关键的MetS成分与纤维化增加相关.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢健康 代谢健康
- 病理学 病理学 病理学
背景情况:
- 前列腺纤维化,标志着肌纤维细胞和原积累,与下泌尿道症状 (LUTS) 和潜在的尿道阻塞有关.
- 代谢综合征 (MetS) 是一组包括中心肥胖,高血糖,失脂症和高血压在内的疾病,因其在前列腺疾病中的炎症作用越来越受认可.
研究的目的:
- 调查代谢综合征 (MetS) 与前列腺纤维化程度之间的关联.
- 为了确定MetS的成分是否与前列腺纤维化严重程度相关.
主要方法:
- 从2021年6月至2022年8月期间接受前列腺手术的108名患者的临床数据的前景收集.
- 根据MetS诊断将患者分为两组,然后进行马森三色染色和定量形态测量,以评估围尿管前列腺纤维化.
主要成果:
- 39.8%的患者被诊断为MetS,前列腺纤维化显著增加 (68.1%与42.5%,P<0.001).
- 在MetS成分数量和前列腺纤维化程度之间发现了正相关性 (R2 = 0.4436,P < 0.001).
- 多变量分析表明,中心肥胖,快餐葡萄糖升高,HDL胆固醇降低和甘油三升高与前列腺纤维化增加独立相关;高血压没有.
结论:
- 前列腺纤维化与代谢综合征正相关.
- 特定的MetS成分,包括中心肥胖,高禁食葡萄糖,降低的HDL胆固醇和高甘油,与前列腺纤维化有显著的关联.
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