PAM试验协议:在晚期癌症患者中进行迷幻微剂量辅助意义中心心理治疗的随机可行性研究
Alesha Wells1, A P Suresh Muthukumaraswamy2, Eva Morunga3,4
1Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22-30 Park Avenue, Grafton, Auckland, 1023, New Zealand. alesha.wells@auckland.ac.nz.
Pilot and feasibility studies
|February 12, 2024
概括
这项研究将评估向晚期癌症患者提供迷幻微量剂与心理治疗相结合的可行性. 结果将指导未来的试验,以减少这一群体的心理痛苦.
科学领域:
- 精神病学和心理治疗
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 晚期癌症诊断与严重的心理痛苦有关.
- 迷幻化合物在治疗晚期癌症患者的痛苦方面表现有前途.
- 迷幻微剂提供了一个务实的方法,可以及时干预.
研究的目的:
- 评估一个全面的随机对照试验的可行性.
- 将迷幻微剂量辅助意义中心心理治疗 (PA-MCP) 与标准MCP进行比较.
- 评估土著 (毛利) 和非土著先进癌症患者的PA-MCP,患有焦虑/抑郁症.
主要方法:
- 40名参与者 (20名毛利族,20名非毛利族) 患有晚期癌症和焦虑/抑郁症状.
- 随机双盲试验:MCP的7次会议与13剂LSD微剂或安慰剂.
- 在多个时间点记录的可行性,可接受性,安全性和心理/生理测量.
主要成果:
- 将评估PA-MCP的可行性,可接受性和安全性.
- 对心理困扰的潜在益处的初步迹象.
- 数据将为更大的随机对照试验的设计提供信息.
结论:
- 该研究将确定对PA-MCP进行更大规模试验的可行性.
- 结果将提供关于迷幻微剂对癌症患者痛苦的疗效的初步见解.
- 结果将指导未来的研究,将迷幻微剂纳入癌症治疗中.
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