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进原素哈普洛缺陷调解了细胞质TDP-43聚合与人类微质细胞的溶解体异常

Wonjae Sung1, Min-Young Noh1, Minyeop Nahm2

  • 1Department of Neurology, College of Medicine, Hanyang University, 222, Wangsimni-Ro, Seongdong-Gu, Seoul, 04763, Republic of Korea.

Journal of neuroinflammation
|February 12, 2024
PubMed
概括

进子素 (PGRN) 基因变异通过损害微质功能引起前性痴呆 (FTD),导致TDP-43聚合和神经炎症. 这项研究揭示了PGRN缺陷FTD中的微质TDP-43病理,为神经退行性机制提供了洞察力.

关键词:
在前性痴呆症.大粒素是什么? 大粒素是什么?炎症 炎症是一种炎症.微质细胞中的微质细胞包含TDP-43的内容

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