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患有充血性心力衰竭的儿童的非甲状腺疾病
Biswajit Sahoo1, Aashima Dabas1, Binita Goswami2
1Maulana Azad Medical College and Lok Nayak Hospital, Clinic of Pediatrics, New Delhi, India
Journal of clinical research in pediatric endocrinology
|February 13, 2024
概括
非甲状腺疾病 (NTI) 影响了近一半患有先天性心脏病 (CHD) 和充血性心力衰竭 (CHF) 的儿童. 低fT3水平与这些儿科患者的NTI严重程度和死亡风险增加有关.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 儿童心脏病学 儿童心脏病学
- 关键护理医学 关键护理医学
背景情况:
- 先天性心脏病 (CHD) 和充血性心力衰竭 (CHF) 是儿童群体的重大健康问题.
- 非甲状腺疾病 (NTI) 是一种复杂的内分泌功能障碍综合征,在重症患者中观察到.
- 了解NTI患病率及其对患有CHF的儿科CHD的影响,对于风险分层和管理至关重要.
研究的目的:
- 确定患有CHD和CHF的儿童中经历NTI的比例.
- 在这个脆弱的儿科队列中确定与NTI相关的风险因素.
- 调查NTI,疾病严重程度和死亡率之间的关系.
主要方法:
- 预计将招收80名患有心脏病和心脏不全症的儿童 (6周至60个月).
- 使用儿科早期预警分数 (PEWS) 评估临床概况,疾病严重程度.
- 在住院时测量甲状腺激素 (fT3,ft4,TSH,逆T3) 和NT-pro-BNP.
主要成果:
- 在46%的入学儿童中诊断出NTI,在27%的儿童中fT3水平低.
- 在患有严重心脏病和心脏病的儿童中,NTI的患病率显著更高 (p=0.018).
- NTI与显著增加的死亡风险相关 (OR:7.593,p=0.006);PEWS独立预测死亡率.
结论:
- 在患有心脏病和心脏病的儿童中,NTI普遍存在,与疾病严重程度相关.
- 低fT3水平与NT-pro-BNP显著相关,表明CHF严重程度.
- NTI是患有心血管疾病和心血管衰竭的儿科患者死亡率的独立预测因子.
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