延迟发作的肌肉疼痛会改变机械灵敏度,但不会改变热灵敏度或疼痛调节功能
Jessica Peterson1,2,3, Grant Chesbro1, Michael G Bemben1
1Department of Health and Exercise Science, University of Oklahoma, Norman, OK, USA.
Journal of pain research
|February 13, 2024
概括
运动引起的肌肉损伤会导致局部疼痛敏感性,与影响整个身体的慢性炎症性疼痛不同. 这项研究使用运动来模拟急性炎症并评估疼痛反应.
科学领域:
- 疼痛研究 疼痛研究
- 运动生理学 运动生理学
- 肌肉骨健康 肌肉骨健康
背景情况:
- 慢性肌肉骨疼痛通常涉及炎症,使 nociceptors 变得敏感.
- 目前尚不清楚炎症是否会对所有感觉受体均地产生影响.
- 运动引起的肌肉损伤 (EIMD) 为研究健康个体的炎症性疼痛提供了一个模型.
研究的目的:
- 调查EIMD对各种疼痛刺激的敏感性的影响.
- 评估EIMD对中央疼痛处理和内源性疼痛调节的影响.
- 在急性EIMD模型中比较炎症性疼痛反应与慢性疼痛状况.
主要方法:
- 18名健康参与者在奇特的膝盖延伸协议之前和之后进行了疼痛敏感性测试,该协议旨在诱导肌肉损伤.
- 该方案涉及6轮10个古怪的膝盖延伸,通过力量减少,运动范围的变化和延迟发作的肌肉疼痛 (DOMS) 来量化EIMD.
- 使用压力和热刺激来评估疼痛敏感性,并通过感知性曲反射评估中央疼痛处理.
主要成果:
- 在运动后受损腿部观察到压力疼痛敏感度显著下降 (p=0.002).
- 没有发现热疼痛敏感度的显著变化.
- 中央疼痛处理和内源性疼痛调节没有受到EIMD协议的显著改变.
结论:
- 由EIMD引起的急性炎症主要导致局部外周过敏对机械刺激.
- 这种局部反应与慢性炎症性疼痛疾病中普遍存在的过敏性形成鲜明对比.
- EIMD可能无法完全复制慢性炎症性疼痛的全球性 nociceptor 敏感化特征.
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