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苏林达克 (OXT-328) 预防和逆转化疗诱导的小鼠外周神经病变

Aryah Basu¹, Jennifer Y Yang¹, Vasiliki E Tsirukis¹

¹Departments of Preventive Medicine, Stony Brook University, Stony Brook, NY, United States.

Frontiers in neuroscience

|February 13, 2024

概括

局部用索林达克 (PS) 有效地治疗和预防化疗诱导的周围神经病变 (CIPN),而不会影响抗癌疗效. 这种修改后的NSAID显示了通过减少神经炎症来管理CIPN的前景.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
在瘤学瘤学.

背景情况:

化疗诱导的周围神经病变 (CIPN) 是癌症治疗的削弱性副作用.
目前对CIPN的治疗方法有限,需要新的治疗方法.

研究的目的:

调查修改型非类固醇抗炎药物 (NSAID) 福苏林达克 (PS) 在治疗和预防CIPN.的疗效.
评估PS是否会影响帕克利塔塞尔的抗癌疗效.

主要方法:

在小鼠中使用帕克利塔塞尔,温克里斯或氧沙来诱导CIPN.
机械和冷均分别使用弗雷和酸盐测试进行测量.
施用PS局部评估其治疗和预防作用,并评估其对神经炎症的影响在细胞系中.

主要成果:

在CIPN模型中,局部PS显著降低了机械和冷体,以剂量依赖的方式.
在肺癌异种移植模型中,PS证明了对CIPN的预防性有效性,并且没有干扰帕克利塔塞尔的抗癌作用.
它抑制了促炎性标记物 (IL-6,IL-10,CXCL1,CXCL2) 和M1巨细胞激活,这表明它在减少神经炎症方面发挥了作用.

结论:

局部PS对CIPN具有广泛的治疗和预防效果.
PS是安全的,并保留了帕克利塔塞尔的抗癌活性.
部分通过抑制神经炎症来调解PS的抗CIPN作用,支持其进一步评估CIPN管理.

关键词:

化疗诱导的周围神经病变 (CIPN)机械的全天体运动.神经炎症是一种神经炎症.帕克利塔克塞尔 (paclitaxel) 是一种药物.酸盐的含量是什么? 酸盐的含量是什么?预防/治疗CIPNN的方法

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