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自闭症谱系障碍患者的过度死亡率:基于人口的队列研究
Yu-Hsin Huang1,2, Shu-I Wu1,2, Min-Jing Lee3,4,5
1Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
自闭症谱系障碍 (ASD) 与较高的死亡率有关. 这种风险对于女性和智力残疾 (ID) 的人来说特别高.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 以前关于自闭症和死亡率的研究已经产生了不一致的结果.
- 性别和智力障碍对自闭症相关死亡率的影响需要进一步调查.
研究的目的:
- 调查ASD和全因死亡率之间的关联.
- 检查性别和智力障碍对ASD患者死亡风险的影响.
主要方法:
- 一项基于人口的队列研究,利用台湾国家健康保险研究数据库和国家死亡登记.
- 包括75,946名患有ASD的患者和75,946名没有ASD的匹配对照.
- 使用Cox比例危险模型和分层分析进行分析.
主要成果:
- 与对照组相比,患有自闭症的个体的全因死亡率显著更高 (aHR 1.64,95% CI 1.54-1.75).
- 伴随性智力障碍 (ID) 增加了死亡风险,在女性中观察到更强烈的关联.
- 在患有智障的ASD人群中,发现自然死亡率的几率比较高.
结论:
- 自闭症与死亡率的增加有关.
- 性别和智力障碍是改变自闭症死亡风险的重要因素.
- 针对性干预和支持对于ASD人口中高风险子组至关重要.
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