渐进式角质的跨皮质加速交联:对中期治疗结果的批判性分析
Rodrigo Vilares-Morgado1,2, Ana Margarida Ferreira1,2, Ana Maria Cunha1,2
1Department of Ophthalmology, Centro Hospitalar Universitário de São João, Porto, Portugal.
Clinical ophthalmology (Auckland, N.Z.)
|February 13, 2024
概括
经皮质加速角膜原交联 (TE-ACXL) 对于进展性角膜 (KC) 是安全的. 然而,它的4年有效性是不令人满意的,许多眼睛的进展需要进一步的治疗.
科学领域:
- 眼科医生 眼科 眼科
- 角膜外科手术 角膜外科手术
- 视觉科学 视觉科学 视觉科学
背景情况:
- 角膜 (KC) 是一种渐进的角膜脱光症,导致视力受损.
- 角膜原交联 (CXL) 旨在阻止KC的进展.
- 跨皮加速CXL (TE-ACXL) 提供了一种不那么侵入性的方法.
研究的目的:
- 评估TE-ACXL在治疗渐进性角质的4年结果.
- 在长期随访期间评估TE-ACXL的安全性和有效性.
主要方法:
- 一组41只眼睛的渐进式KC接受了TE-ACXL.
- 角膜拓,断层扫描,视力敏度和心智测量被监测了48个月.
- 进展是由特定的增长的角质量测量,下降后角膜曲率,或角膜厚度的稀薄定义.
主要成果:
- 观察到平均角质量显著增加 (Kmean) 和后侧曲率半径 (PRC) 显著减少.
- 角膜厚度 (PachyMin) 在36个月和48个月显著下降.
- 在整个4年随访期间,观察到高进展率 (超过57%),其中26.8%的眼睛需要进一步的手术.
结论:
- TE-ACXL证明了渐进性角质治疗的安全性.
- 由于大量眼睛的疾病进展显著,TE-ACXL的长期疗效被认为是不令人满意的.
- 可能需要额外的干预措施来管理TE-ACXL后的持续性渐进性角.
更多相关视频
05:56Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
8.9K
12:25Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
Published on: January 6, 2018
7.8K
相关概念视频
Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
