凝分散的纳米结构脂质载体装载甲状腺被设计用于皮肤病理
Camila Folle1, Ana M Marqués2, Natalia Díaz-Garrido3,4,5
1Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
International journal of nanomedicine
|February 13, 2024
概括
在这项研究中,开发了用于治疗的含醇的纳米结构脂质载体 (NLC). 这种新的配方有效地向菌,同时保留有益的皮肤微生物,提供了一个有前途的局部治疗方法.
科学领域:
- 皮肤病学和纳米技术
- 药理学和药物输送 药理学和药物输送
背景情况:
- 是一种常见的皮肤疾病,没有确定的治疗方法.
- 目前的治疗方法往往会破坏皮肤的自然微生物群.
- 需要有针对性的治疗方法,以保持健康的皮肤菌群.
研究的目的:
- 开发和优化用于局部治疗的提摩尔载荷纳米结构脂质载体 (NLC).
- 为了评估NLC配方的物理化学特性,稳定性和皮肤保留性.
- 评估抗菌药物对导致的细菌的有效性,同时不影响有益的皮肤微生物.
主要方法:
- 纳米结构脂质载体 (NLC) 封装硫醇是通过超声波或高压均质化制备的.
- 配方使用2^2星系因数设计进行了优化,并采用了各种物理化学技术.
- 评估了稳定性,细胞活力 (HaCat细胞) 和抗菌活性 (体外和体外).
- 载有甲状腺素的NLC被分散在各种凝中,并选择碳合物以获得最佳的皮肤保留.
主要成果:
- 优化的NLC表现出长时间的乳腺醇释放和良好的物理化学特性.
- 基于碳烯的凝显示出高皮肤保留,特别是在表皮和皮肤.
- 含甲基醇的NLC凝对*C. acnes*具有显著的抗菌疗效.
- 与自由甲状腺醇相比,NLC配方对*S. epidermidis*的活性降低,这表明微生物群的保存.
结论:
- 提摩尔载荷的NLC成功封装并输送了用于局部应用的提摩尔.
- 开发的凝系统是治疗的有希望的候选人.
- 该配方有效地向致病性细菌,同时可能保护健康的皮肤微生物群.
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