急性中度强度循环对cfDNA水平的影响,考虑到月经周期阶段
Akemi Sawai1,2, Takashi Shida2,3, Yoshihiro Hoshikawa4
1Research Institute of Physical Fitness, Japan Women's College of Physical Education, Setagaya City, Japan.
Frontiers in sports and active living
|February 13, 2024
概括
运动会增加运动后的无细胞DNA (cfDNA) 水平,其大小受月经周期阶段和卵巢激素的影响. 休息的cfDNA不受月经周期的影响.
科学领域:
- 运动生理学 运动生理学
- 生殖内分泌学 生殖内分泌学
- 分子生物学分子生物学
背景情况:
- 无细胞DNA (cfDNA) 是细胞循环和压力的生物标志物.
- 卵巢激素在整个月经周期中波动,可能会影响对运动的生理反应.
- 久坐不动的人提供了一个基线来评估运动诱导的变化.
研究的目的:
- 研究运动对月经周期不同阶段的cfDNA水平的影响.
- 为了检查卵巢激素度和运动后cfDNA变化之间的关系.
- 为了确定静止cfDNA水平在月经周期期间是否有变化.
主要方法:
- 在月经,排卵和黄体阶段,11名静坐的女学生在60%的VO2max下进行了30分钟的自行车运动.
- 血液样本在运动前收集,并在运动后的0,30分钟和60分钟收集.
- 测量了cfDNA,卵巢激素 (雌激素和孕激素) 和芳酶的度.
主要成果:
- 休息时cfDNA水平在月经周期各阶段没有显著差异.
- 在所有阶段,cfDNA和芳酶度在运动后立即显著增加.
- 运动后cfDNA的增加是由卵巢激素水平调节的,显示出在排卵和卵期的孕激素与雌激素比率的负相关性.
结论:
- 运动暂时会提高cfDNA水平,而反应受到月经周期阶段特定的荷尔蒙环境的影响.
- 卵巢激素,特别是孕激素和雌激素,似乎调节运动诱导的cfDNA增加.
- 静止cfDNA水平在久坐不动的女性中不会受到月经周期的显著影响.
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