非披露性数据分析的优点和局限性:使用VisualSHIELD对乳腺癌存活率分类器进行比较
Danilo Tomasoni1, Rosario Lombardo2, Mario Lauria1,3
1Fondazione the Microsoft Research-University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Frontiers in genetics
|February 13, 2024
概括
数据隐私对于患者数据研究至关重要. 这项研究使用联合的DataSHIELD系统评估了乳腺癌分类器,发现后勤回归表现最好,尽管由于隐私限制,性能下降了4%.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 生物统计学 生物统计学
背景情况:
- 患者数据的隐私在研究中至关重要.
- 数据盾 (DataSHIELD) 在联合环境中提供隐私意识的统计分析.
- 挑战包括基础设施的复杂性,性能和可用性.
研究的目的:
- 在一个联邦,保护隐私的环境中审查乳腺癌分类器.
- 在现实的环境中评估非披露工具的性能和局限性.
- 将联合分类器的性能与不受约束的分析进行比较.
主要方法:
- 通过联合基础设施 (DataSHIELD) 将五个独立的乳腺癌生存基因表达数据集汇集在一起.
- 培训了3个已发表的和2个新的5年无癌症生存风险分类器.
- 一个参考分类人员接受了训练,获得不受限制的数据访问以进行比较.
主要成果:
- 发表的分类器显示不同患者队列的概括性很差.
- 后勤回归和随机森林在测试方法中显示出最佳的平均性能.
- 不受约束的物流回归分类器的表现大约比其联合对应器高出4%.
结论:
- 使用DataSHIELD进行联合分析对于乳腺癌存活率预测是可行的.
- 逻辑回归在这个框架内提供了一种强大的方法,尽管有很小的性能权衡.
- VisualSHIELD 增强了 DataSHIELD 的可用性和可复制性,以便非技术用户使用.
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