质子抑制剂治疗对骨的影响:一项总体综述
Abdullah S Alanazi1, Hadiah Almutairi2, Jeetendra Kumar Gupta3
1Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Al-Jouf, Saudi Arabia.
Bone reports
|February 13, 2024
概括
长期使用质子抑制剂 (PPI) 可能会增加骨折风险并影响骨健康. 需要进一步的高质量研究来证实这些关联,因为目前证据的确定性很低.
科学领域:
- 骨代谢和药理学的骨代谢和药理学
- 胃肠病学和内科医学
背景情况:
- 质子抑制剂 (PPI) 被广泛用于与酸有关的疾病.
- 长期使用PPI引发了对骨健康潜在不良影响的担忧.
- 这一综合性综述综合了PPI和骨代谢的证据.
研究的目的:
- 进行现有文献的综合审查.
- 综合关于PPI使用与骨代谢结果之间的关联的发现.
- 评估骨折风险,骨矿物质密度 (BMD) 的变化和其他与骨相关的问题.
主要方法:
- 在PubMed,科学网,Embase和Cochrane图书馆进行系统搜索.
- 包括RCT和观察性研究的系统审查和元分析.
- 数据提取,质量评估 (乔安娜·布里格斯研究所,PRISMA) 和证据分类 (GRADE).
主要成果:
- 在PPI使用者中观察到统计学上显著的骨折 (部,脊柱,手腕) 风险增加.
- 使用PPI与骨矿物质密度 (BMD) 的变化有关,尽管临床意义不确定.
- 在PPI使用者中发现了低磁血症和牙植入物失败风险增加.
- 对大多数发现的证据确定性被评为非常低至低.
结论:
- 长期使用PPI可能与不良的骨健康结果有关,包括骨折和改变的BMD.
- 低磁血症和牙植入物失败是长期使用PPI的潜在问题.
- 目前证据的确定性较低,需要高质量的研究来澄清这些关联.
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