热塑性聚氨/POSS纳米混合体:合成,形态和生物特性
Jan Ozimek1, Katarzyna Malarz2,3, Anna Mrozek-Wilczkiewicz2,3
1Department of Chemistry and Technology of Polymers, Cracow University of Technology, Kraków, Poland.
Journal of biomedical materials research. Part B, Applied biomaterials
|February 13, 2024
概括
新的聚氨-POSS纳米混合材料显示出优异的骨质诱导特性,促进显著的酸沉积,并显示出良好的生物相容性,用于骨再生应用.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 纳米技术 纳米技术
背景情况:
- 聚氨 (PU) 是具有生物医学应用潜力的多功能聚合物.
- 用多面寡合性丝二氧化 (POSS) 修改PU可以增强其性能.
- 骨诱导性是骨再生材料的一个关键性质.
研究的目的:
- 为了合成和描述新型纳米混合型聚氨-POSS材料.
- 研究这些新材料的骨质诱导潜力和生物相容性.
- 探索不同POSS类型和组合对材料性能的影响.
主要方法:
- 三种POSS类型 (PHI-POSS,DSI-POSS,OCTA-POSS) 在线性PU中进行化学结合.
- 使用FTIR-ATR,SEM-EDS和DSC进行表征.
- 通过SBF浸泡和酸沉积分析进行骨质诱导性的体外评估.
- 生物相容性评估使用纤维细胞和骨质细胞细胞系的细胞毒性测试.
主要成果:
- 成功合成了热塑性PU-POSS纳米混合材料,具有良好的回收.
- 在SBF浸泡后观察到显著的酸沉积 (~60-40微米),Ca/P比高达1.785.
- 根据POSS类型和PU组成的可定制无机层特性.
- 细胞活力优异 (>90%) 和纤维细胞和骨质细胞在材料上的附着.
结论:
- 开发的PU-POSS纳米混合体表现出有前途的骨质诱导能力.
- 这些材料表现出良好的生物相容性,支持细胞粘附,活力和增殖.
- 这些复合材料的可调性使它们成为骨组织工程支架的合适候选者.
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