在老年患者中,皮下或静脉注射塞夫特里亚克森的安全性:一项回顾性研究
Inès Pardo1, Morgane Pierre-Jean2, Guillaume Bouzillé3
1Univ Rennes, CHU Rennes, Service de Gériatrie, Rennes, France.
Journal of the American Geriatrics Society
|February 13, 2024
概括
与静脉注射相比,在老年人中,皮下使用塞夫特里亚克森的不良事件较少. 这种途径为老年患者的感染管理提供了安全有效的选择.
科学领域:
- 老年医学 老年医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素对于治疗感染至关重要,特别是在老年患者中.
- 在老年人中,皮下注射抗生素是常见的.
- 虽然已知 ceftriaxone 的药理动力学,但其通过皮下途径的安全性需要更多的数据.
研究的目的:
- 为了在75岁及以上的患者中比较皮下和静脉注射塞夫的不良事件.
- 为了评估不同 ceftriaxone 给药途径在老年人中的安全性和结果.
主要方法:
- 来自雷恩大学医院的临床行政数据库的回顾性分析.
- 皮下和静脉注射塞夫triaxone组之间的14天的不良事件和21天的结果的比较.
- 包括在2020年5月至2023年2月期间接受塞夫特里亚的75岁以上的患者.
主要成果:
- 该研究包括402名皮下注射组的患者和3387名静脉注射组的患者.
- 18%的皮下小组患者经历了不良事件,而静脉注射组的不良事件为40% (RR=2.21).
- 皮下注射组的21日死亡率较高,可能是由于人口统计学差异.
结论:
- 在75岁以上的患者中,皮下使用的塞夫特里亚克森与静脉注射相比,不良事件的发生较少.
- 皮下注射是一种可行的,更容易使用的选择,用于老年护理中的感染管理.
- 鉴于患者的特征,可能需要对死亡率差异进行进一步调查.
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