与癌症相关的非细菌性血栓性内心炎-来自单一机构的临床系列
Patryk Patrzalek1,2, Waldemar E Wysokinski1,2, Reto D Kurmann1,2
1Cardiovascular Disease, Gonda Vascular Center, Mayo Clinic, Rochester, Minnesota, USA.
American journal of hematology
|February 13, 2024
概括
与癌症相关的非细菌性血栓性内心炎 (Ca-NBTE) 主要影响患有肺癌或消化系统癌症的女性,通常以中风的形式呈现. 这种情况带来了高死亡率和在抗凝治疗期间频繁的栓塞和出血并发症.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 与癌症相关的非细菌性血栓性内心炎 (Ca-NBTE) 是一种罕见的疾病,对其临床表现,治疗和结果的数据有限.
- 现有的知识主要基于案例报告和小案例系列,需要更大的研究来全面理解.
研究的目的:
- 研究Ca-NBTE患者的临床表现,治疗干预和临床过程.
- 在接受抗凝治疗的Ca-NBTE患者中分析栓塞和出血并发症的发生率.
主要方法:
- 使用梅奥诊所 (2002年3月至2022年6月) 电子病历进行的回顾性队列研究.
- 纳入标准:成年患者心声检测NBTE和活跃恶性瘤,不包括传染性内心炎或抗脂抗体.
- 数据分析包括患者人口统计学,癌症类型,膜卷入,栓塞事件,抗凝治疗,出血并发症和死亡率.
主要成果:
- 确定了115名Ca-NBTE患者 (平均年龄63.2岁,66.1%的女性),肺癌 (39.1%) 和胰腺癌 (16.5%) 是最常见的.
- 血栓并发症在呈现时很常见 (81.7%的脑栓塞).
- 动脉血栓栓塞的两年发病率为15.9%,静脉血栓塞的8.9%,在抗凝时有12.8%的重大出血率. 总体死亡率为77.9%.
结论:
- Ca-NBTE主要影响患有肺腺癌或消化道癌症的女性.
- 这种情况经常表现为中风,与高死亡率和抗凝药期间显著的栓塞和出血风险有关.
- 需要进一步的研究来优化Ca-NBTE的管理策略.
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