代谢功能障碍相关的脂肪肝疾病与心力衰竭之间的关系中的性别和年龄差异:一项前性队列研究
Shouling Wu1, Yuhao Li2,3, Yijun Zhang2
1Department of Cardiology, Kailuan General Hospital, Tangshan, China (S.W., S.C.).
Circulation. Heart failure
|February 13, 2024
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 显著增加心力衰竭 (HF) 的风险,特别是在年轻女性中. 这种风险随着年龄的增长而减少,与MAFLD相关的HF风险的性别差异在老年人群中变得可以忽略不计.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是心力衰竭 (HF) 的已知的危险因素.
- 然而,性别和年龄对MAFLD和HF风险之间的关联的影响仍然不完全理解.
研究的目的:
- 调查MAFLD对不同年龄组和性别心力衰竭风险的影响.
主要方法:
- 利用了Kailuan研究中的96,576名参与者的数据.
- MAFLD的诊断是使用超声波诊断肝脏肥胖症和代谢功能障碍的标准.
- 考克斯回归模型用于计算危险比率 (HRs) 和评估风险,平均随访时间为14.0年.
主要成果:
- 轻度和显著的MAFLD都与HF风险增加有关 (HR分别为1.27和1.45).
- MAFLD和HF风险之间的关联因性别 (Pinteraction<0.05) 和年龄 (Pinteraction<0.001) 有显著差异.
- 显著的MAFLD在女性中增加了84%的HF风险,而在男性中增加了36%. 年轻人 (<45岁) 与老年人 (>65岁) 相比面临更高的风险 (轻微的MAFLD:55%,显著的MAFLD:172%) ,即使显著的MAFLD也没有增加风险.
结论:
- MAFLD显著增加了HF风险,对女性,尤其是年轻女性有明显的影响.
- 随着年龄的增长,MAFLD相关的HF风险在两性中都会降低.
- 与MAFLD相关的HF风险的性别差异随着年龄的增长而减少,在45岁以下的个体中最明显.
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